Original Research

Published on 19 Jan 2024

Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor

in Medicinal and Pharmaceutical Chemistry

Amal Amaghnouje
Mohamed Chebaibi
Saeed M. Aldossari
Hazem K. Ghneim
Fatima Ez-zahra Amrati
Imane Es-Safi
Francesca Di Cristo
Anna Calarco
Sanae Achour
Fabrizio Carta

Frontiers in Chemistry

doi 10.3389/fchem.2023.1257769

130 views

Original Research

Published on 19 Jan 2024

Chemical composition, antioxidant, and antimicrobial properties of Mentha subtomentella: in sight in vitro and in silico analysis

in Medicinal and Pharmaceutical Chemistry

Fatima Brahmi
Nour Eddine Bentouhami
Youssef Rbah
Amine Elbouzidi
Ouafae Mokhtari
Ahmad Mohammad Salamatullah
Samir Ibenmoussa
Mohammed Bourhia
Mohamed Addi
Abdeslam Asehraou

Frontiers in Chemistry

doi 10.3389/fchem.2023.1341704

222 views

Original Research

Published on 16 Jan 2024

ROS-dependent catalytic mechanism of melatonin metabolism and its application in the measurement of reactive oxygen

in Medicinal and Pharmaceutical Chemistry

Xiangge Tian
Xiaohui Kang
Fei Yan
Lei Feng
Xiaokui Huo
Houli Zhang
Yan Wang
Xia Lv
Xiaochi Ma
Jinsong Yuan

Frontiers in Chemistry

doi 10.3389/fchem.2023.1229199

191 views

Original Research

Published on 16 Jan 2024

Elucidating the binding mechanism of SARS-CoV-2 NSP6-TBK1 and structure-based designing of phytocompounds inhibitors for instigating the host immune response

in Medicinal and Pharmaceutical Chemistry

Muhammad Suleman
Iqra Ishaq
Haji Khan
Safir Ullah khan
Rehana Masood
Norah A. Albekairi
Abdulrahman Alshammari
Sergio Crovella

Frontiers in Chemistry

doi 10.3389/fchem.2023.1346796

375 views

Review

Accepted on 12 Jan 2024

Aconitine and its derivatives: Bioactivities, structure-activity relationships and preliminary molecular mechanisms

in Medicinal and Pharmaceutical Chemistry

Pengyu Zhao
Ye Tian
Yuefei Geng
Chenjuan Zeng
Xiuying Ma
Jie Kang
Lin Lu
Xin Zhang
Bo Tang
Funeng Geng

Frontiers in Chemistry

doi 10.3389/fchem.2024.1339364

Original Research

Published on 11 Jan 2024

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups

in Medicinal and Pharmaceutical Chemistry

Tomáš Vašíček
Benjamin Arensmeyer
Alessandro Monti
Alla Zamyatina

Frontiers in Chemistry

doi 10.3389/fchem.2023.1332837

460 views

Editorial

Published on 11 Jan 2024

Editorial: Recent advances in medical radiation technology

in Medicinal and Pharmaceutical Chemistry

Samir Acherar

Frontiers in Chemistry

doi 10.3389/fchem.2024.1360379

432 views

Review

Published on 10 Jan 2024

Research progress of plant-derived natural products in thyroid carcinoma

in Medicinal and Pharmaceutical Chemistry

Qiujing Du
Weidong Shen

Frontiers in Chemistry

doi 10.3389/fchem.2023.1279384

247 views

Review

Published on 10 Jan 2024

Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine

in Medicinal and Pharmaceutical Chemistry

Shahab Ur Rehman
Numan Ullah
Zhenbin Zhang
Yongkang Zhen
Aziz-Ud Din
Hengmi Cui
Mengzhi Wang

Frontiers in Chemistry

doi 10.3389/fchem.2023.1335330

266 views

Original Research

Published on 10 Jan 2024

Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways

in Medicinal and Pharmaceutical Chemistry

Yong-Qiang Tian
Jing Liu
Peng Cheng
Jian Zou
Hui-Fang Xu
Xin-Hua Shi
Yi-Sheng Zhang
Ling Mei

Frontiers in Chemistry

doi 10.3389/fchem.2023.1287570

259 views

Original Research

Accepted on 08 Jan 2024

Integrating Computational Methods Guided the discovery of Phytochemicals as Potential Pin1 Inhibitors for Cancer: Pharmacophore modeling, Molecular Docking, MM-GBSA Calculations and Molecular Dynamics studies

in Medicinal and Pharmaceutical Chemistry

Abdulrahim A. Alzain
Fatima Abdelazeem
Tagyedeen H. Shoaib
Asmaa E. Sherif
Wadah Osman
Ahmed Ashour
Gamal A. Mohamed
Sabrin R. M. Ibrahim
Eun Joo Roh
Ahmed H.E. Hassan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1339891

Original Research

Published on 08 Jan 2024

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome

in Medicinal and Pharmaceutical Chemistry

Pedro M. P. Fernandes
Romina A. Guedes
Bruno L. Victor
Jorge A. R. Salvador
Rita C. Guedes

Frontiers in Chemistry

doi 10.3389/fchem.2023.1322628

638 views

Original Research

Accepted on 03 Jan 2024

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

in Medicinal and Pharmaceutical Chemistry

Syed Mohd Danish Rizvi
Ibrahim Almazni
Mamdoh S Moawadh
Zeyad M Alharbi
Nawal Helmi
Leena S Alqahtani
Talib Hussain
Ahmed Alafnan
Afrasim Moin
Abdelmoneim O Elkhalifa

Frontiers in Chemistry

doi 10.3389/fchem.2024.1352009

Original Research

Published on 03 Jan 2024

Antioxidant and anticholinesterase properties of Echinometra mathaei and Ophiocoma erinaceus venoms from the Persian Gulf

in Medicinal and Pharmaceutical Chemistry

Hamideh Dehghani
Marzieh Rashedinia
Gholamhossein Mohebbi
Amir Vazirizadeh
Neda Baghban

Frontiers in Chemistry

doi 10.3389/fchem.2023.1332921

1,557 views

Original Research

Accepted on 29 Dec 2023

Pb-214/Bi-214-TCMC-Trastuzumab Inhibited Growth of Ovarian Cancer in Preclinical Mice Models

in Medicinal and Pharmaceutical Chemistry

Abdullah Metebi
Nathan Kauffman
Lucy Xu
Satyendra Kumar Singh
Chelsea Nayback
Jinda Fan
Nathan Johnson
John Diemer
Terry Grimm
Mike Zamiara

Frontiers in Chemistry

doi 10.3389/fchem.2023.1322773

Review

Published on 22 Dec 2023

Development of fluorophores for the detection of oligomeric aggregates of amyloidogenic proteins found in neurodegenerative diseases

in Medicinal and Pharmaceutical Chemistry

Kristine L. Teppang
Qilin Zhao
Jerry Yang

Frontiers in Chemistry

doi 10.3389/fchem.2023.1343118

590 views

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Articles

Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor

Chemical composition, antioxidant, and antimicrobial properties of Mentha subtomentella: in sight in vitro and in silico analysis

ROS-dependent catalytic mechanism of melatonin metabolism and its application in the measurement of reactive oxygen

Elucidating the binding mechanism of SARS-CoV-2 NSP6-TBK1 and structure-based designing of phytocompounds inhibitors for instigating the host immune response

Aconitine and its derivatives: Bioactivities, structure-activity relationships and preliminary molecular mechanisms

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups

Editorial: Recent advances in medical radiation technology

Research progress of plant-derived natural products in thyroid carcinoma

Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine

Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways

Integrating Computational Methods Guided the discovery of Phytochemicals as Potential Pin1 Inhibitors for Cancer: Pharmacophore modeling, Molecular Docking, MM-GBSA Calculations and Molecular Dynamics studies

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

Antioxidant and anticholinesterase properties of Echinometra mathaei and Ophiocoma erinaceus venoms from the Persian Gulf

Pb-214/Bi-214-TCMC-Trastuzumab Inhibited Growth of Ovarian Cancer in Preclinical Mice Models

Development of fluorophores for the detection of oligomeric aggregates of amyloidogenic proteins found in neurodegenerative diseases