Original Research

Published on 27 Jan 2021

Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations

in Structural Biology

Giang Thi Tuyet Nguyen
Aleksi Sutinen
Arne Raasakka
Gopinath Muruganandam
Remy Loris
Petri Kursula

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.631232

5,415 views
12 citations

Original Research

Published on 12 Jan 2021

pH-Induced Local Unfolding of the Phl p 6 Pollen Allergen From cpH-MD

in Structural Biology

Florian Hofer
Anna S. Kamenik
Monica L. Fernández-Quintero
Johannes Kraml
Klaus R. Liedl

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.603644

2,377 views
5 citations

Original Research

Published on 08 Jan 2021

Rapid Structural Analysis of a Synthetic Non-canonical Amino Acid by Microcrystal Electron Diffraction

in Structural Biology

Patrick R. Gleason
Brent L. Nannenga
Jeremy H. Mills

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.609999

2,636 views
5 citations

Original Research

Published on 07 Jan 2021

Solvent Accessibility of Residues Undergoing Pathogenic Variations in Humans: From Protein Structures to Protein Sequences

in Structural Biology

Castrense Savojardo
Matteo Manfredi
Pier Luigi Martelli
Rita Casadio

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.626363

14,073 views
59 citations

Original Research

Published on 06 Jan 2021

Protein and Organic-Molecular Crystallography With 300kV Electrons on a Direct Electron Detector

in Structural Biology

Kiyofumi Takaba
Saori Maki-Yonekura
Satoru Inoue
Tatsuo Hasegawa
Koji Yonekura

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.612226

4,380 views
18 citations

Review

Published on 17 Dec 2020

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

in Structural Biology

Giuseppina Mariano
Rebecca J. Farthing
Shamar L. M. Lale-Farjat
Julien R. C. Bergeron

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.605236

58,255 views
169 citations

Review

Published on 04 Dec 2020

Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19

in Structural Biology

Wen Cui
Kailin Yang
Haitao Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.616341

20,774 views
82 citations

Original Research

Published on 24 Nov 2020

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

in Structural Biology

Monica L. Fernández-Quintero
Katharina B. Kroell
Martin C. Heiss
Johannes R. Loeffler
Patrick K. Quoika
Franz Waibl
Alexander Bujotzek
Ekkehard Moessner
Guy Georges
Klaus R. Liedl

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.609088

3,511 views
11 citations

Original Research

Published on 20 Nov 2020

Known Evolutionary Paths Are Accessible to Engineered ß-Lactamases Having Altered Protein Motions at the Timescale of Catalytic Turnover

in Structural Biology

Lorea Alejaldre
Claudèle Lemay-St-Denis
Carles Perez Lopez
Ferran Sancho Jodar
Victor Guallar
Joelle N. Pelletier

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.599298

2,430 views
3 citations

Original Research

Published on 06 Nov 2020

Properties of Cavities in Biological Structures—A Survey of the Protein Data Bank

in Structural Biology

Mateusz Chwastyk
Ewa A. Panek
Jan Malinowski
Mariusz Jaskólski
Marek Cieplak

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.591381

3,024 views
8 citations

Hypothesis and Theory

Published on 02 Oct 2020

Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis

in Structural Biology

Christian Fercher
Lucía F. Zacchi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.585643

1,561 views
3 citations

Original Research

Published on 30 Sep 2020

Asparagine and Glutamine Side-Chains and Ladders in HET-s(218–289) Amyloid Fibrils Studied by Fast Magic-Angle Spinning NMR

in Structural Biology

Thomas Wiegand
Alexander A. Malär
Riccardo Cadalbert
Matthias Ernst
Anja Böckmann
Beat H. Meier

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.582033

6,279 views
11 citations

Review

Published on 25 Aug 2020

Drug Weaponry to Fight Against SARS-CoV-2

in Structural Biology

Elena Cabezón
Ignacio Arechaga

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.00204

5,100 views
2 citations

Original Research

Published on 14 Aug 2020

Cross-Species and Cross-Polymorph Seeding of Lysozyme Amyloid Reveals a Dominant Polymorph

in Structural Biology

Lida Rahimi Araghi
Derek R. Dee

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.00206

3,030 views
11 citations

Review

Published on 07 Aug 2020

Structural Perspectives on Extracellular Recognition and Conformational Changes of Several Type-I Transmembrane Receptors

in Structural Biology

Lucas M. P. Chataigner
Nadia Leloup
Bert J. C. Janssen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.00129

6,892 views
11 citations

Original Research

Published on 06 Aug 2020

Prion Amyloid Polymorphs – The Tag Might Change It All

in Structural Biology

Luc Bousset
Nina Luckgei
Mehdi Kabani
Carole Gardiennet
Anne K. Schütz
Ronald Melki
Beat H. Meier
Anja Böckmann

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.00190

2,117 views
2 citations

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Articles

Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations

pH-Induced Local Unfolding of the Phl p 6 Pollen Allergen From cpH-MD

Rapid Structural Analysis of a Synthetic Non-canonical Amino Acid by Microcrystal Electron Diffraction

Solvent Accessibility of Residues Undergoing Pathogenic Variations in Humans: From Protein Structures to Protein Sequences

Protein and Organic-Molecular Crystallography With 300kV Electrons on a Direct Electron Detector

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

Known Evolutionary Paths Are Accessible to Engineered ß-Lactamases Having Altered Protein Motions at the Timescale of Catalytic Turnover

Properties of Cavities in Biological Structures—A Survey of the Protein Data Bank

Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis

Asparagine and Glutamine Side-Chains and Ladders in HET-s(218–289) Amyloid Fibrils Studied by Fast Magic-Angle Spinning NMR

Drug Weaponry to Fight Against SARS-CoV-2

Cross-Species and Cross-Polymorph Seeding of Lysozyme Amyloid Reveals a Dominant Polymorph

Structural Perspectives on Extracellular Recognition and Conformational Changes of Several Type-I Transmembrane Receptors

Prion Amyloid Polymorphs – The Tag Might Change It All