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Original Research

Published on 26 Nov 2014

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

in Experimental Pharmacology and Drug Discovery

  • Manoranjenni Chetty
  • Rachel H. Rose
  • Khaled Abduljalil
  • Nikunjkumar Patel
  • Gaohua Lu
  • Theresa Cain
  • Masoud Jamei
  • Amin Rostami-Hodjegan
Frontiers in Pharmacology
doi 10.3389/fphar.2014.00258
  • 10,719 views
  • 47 citations