About this Research Topic
This Research Topic aims at collecting studies focusing on the neuronal and non-neuronal responses to electrical stimulation at cellular, circuit, and system levels. This will deepen our understanding of the biological mechanisms underlying the safety and efficacy of the stimulation. Given the complexity of the nervous system, the safety and efficacy of electrical stimulation, including both the device and the stimulation paradigms, requires multifaceted considerations in neuroinflammation, cell-type specificity, neural circuitry adaptation, systemic functional effect, stimulation electrode geometry, electrode material, and electrical field distribution, etc. In addition, considerations need to be given to the interactions among different factors. For example, we should consider how neural tissue changes would impact the effectiveness of the preset stimulation, how electrical stimulation parameters would affect the electrode integrity, and how electrode degradation would change the electrical field distribution, etc.
This Research Topic welcomes Original Research, Systematic Review, Methods, Review, Mini Review, Perspective, and Case Report articles. Topics of interest include, but are not limited to:
Innovative in silico, in vitro, in vivo, and clinical methods to evaluate the safety and efficacy of electrical stimulation.
Original findings in biological responses, including neuronal, glial, vascular, and behavioral changes, to the stimulation.
Safety of materials used in electrical stimulation devices.
Molecular, neurochemical, and neuropeptide measurements as a result of electrical stimulation (such as stimulated dopamine release).
The efficacy and safety study of electrode probes such as metal or conducting polymer stimulating electrodes, carbon fiber microelectrodes, glassy carbon electrodes, microdialysis probes, in vivo fiber photometry, optogenetic probes, and other novel probes
Keywords: Neural stimulation, Safety, Efficacy, neural modulation, electrical stimulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.